Research Focus
Frédéric Allain is Associate Professor at the Institute of Molecular Biology and Biophysics of the ETH in Zürich. His research interests are the NMR structure determination of RNAs, proteins and protein-RNA complexes that are associated in post-transcriptional gene regulation. He has determined the structures of several alternative-splicing factors in complex with RNA, i.e PTB, SRp20 and Fox-1.
Publications
- Morillas, M., Eberl, H., Allain, F.H.-T., Glockshuber, R., Kuennemann, E. (2008), Novel enzymatic activity derived from the Semliki Forest virus capsid protein. Journal of Molecular Biology 376, 721-35.
- Auweter, S.D., Allain, F.H.-T. (2008). Structure-function relationships of the polypyrimidine tract binding protein. Cellular and Molecular Life Sciences 65, 516-27.
- Lapouge, K., Schubert, M,. Allain, F.H.-T., Haas, D. (2008). Gac/Rsm signal transduction pathway of gamma-proteobacteria: from RNA recognition to regulation of social behaviour. Molecular Microbiology 67, 241-253.
- Skrisovska, L., Allain, F.H.-T. (2007). Improved Segmental Isotope Labeling Methods for the NMR Study of Multidomain or Large Proteins: application to the RRMs of Npl3p and hnRNP L. Journal of Molecular Biology 375, 151-164.
- Schubert, M., Lapouge, K., Duss, O., Oberstrass, F.C., Jelesarov, I., Haas, D., Allain, F. H.-T. (2007). Molecular Basis of mRNA Recognition by the Specific Bacterial Repressing Clamp RsmA/CsrA. Nature Structural and Molecular Biology 14, 807-813.
- Skrisovska, L., Bourgeois, C.F., Stefl, R., Grellscheid, S.N., Kister, L., Wenter, P., Elliott, D.J., Stévenin, J., Allain, F.H.-T. (2007). The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. EMBO Reports 8, 372-379.
- Auweter, S.D., Oberstrass, F.C., Allain, F.H.-T. (2007). Solving the Structure of PTB in Complex with Pyrimidine Tracts: An NMR Study of Protein–RNA Complexes of Weak Affinities. Journal of Molecular Biology 367, 174-86.
Lab Website: http://www.mol.biol.ethz.ch/groups/allain_group
|
